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Clinical Manifestations • Extreme fatigue • Hair loss, brittle nails, dry pores and skin, and numbness and tingling of ?ngers • Husky voice and hoarseness • Menstrual disturbances (eg, menorrhagia or amenorrhea); loss of libido • Severe hypothyroidism: subnormal temperature and pulse rate; weight achieve without corresponding enhance in meals consumption; cachexia • Thickened skin, thinning hair or alopecia; expressionless and masklike facial options • Sensation of cold in a heat setting • Subdued emotional responses as the condition progresses; dulled mental processes and apathy • Slowed speech; enlarged tongue, palms, and ft; constipa tion; probably deafness • Advanced hypothyroidism: personality and cognitive changes, pleural effusion, pericardial effusion, and respira tory muscle weak spot 394 Hypothyroidism and Myxedema • Hypothermia: abnormal sensitivity to sedatives, opiates, and anesthetic brokers (these medication are given with excessive warning) • Severe hypothyroidism: elevated serum cholesterol stage, atherosclerosis, coronary artery illness, and poor left ven tricular function • Myxedema coma (uncommon) Gerontologic Considerations the upper prevalence of hypothyroidism in the elderly pop ulation may be related to alterations in immune operate with age. 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Summary the authors present traits and scientific outcomes of 42 patients with preserved left ven- tricular function who underwent stenting of an isolated, unprotected left primary stenosis.
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